I wonder... does Robo-Curie return a Male report?
Try in the command line console, Ryan. Select Curie, and then enter the console command "GetIsSex Female" and see what it reports. I'm going to try on Robo-Curie to see what it returns.
EDIT: It seems that Robo-Curie returns =1 on "GetIsSex Male" and =0 on "GetIsSex Female".
EDIT 2: Okay... not sure if this will trickle down to Synth Curie, but Robo-Curie can be corrected. On the actor form EncCurieRobot (ID:001846CB), she is not checked as female. Checking as female will be reflected immediately for Robo-Curie, but my current (and first) playthru is not far along enough for her to be Synthed to test there. I will continue to play without the temp-fix to get to a state where I can test.